Heart failure category by LVEF: HFrEF, HFmrEF, HFpEF, HFimpEF (Universal Definition 2021) uhf2021_hf_ef_category@1.0
1
Open licence (CC BY)
Draft · pending review draft — pending clinical and coding review
- Status
- draft — pending clinical and coding review (draft — requires clinical and coding review)
- Condition
- Heart failure (EF category)
- Tier
- 1
- Licence
- Open licence (CC BY)
- Source checked
- opened on 2026-11-14: PMC9254673 opened 2026-11-14 in the resourcing build: reduced 40% or lower, mildly reduced 41% to 49%, preserved 50% or higher, improved = baseline 40% or lower, rise of 10 points or more, second above 40%; matches the categories. CC BY 4.0 licence line read on the page.
- Use here
- default set (heart_failure_ef)
- Edition
- 2021 universal definition (as restated in 2022) (2021) (a newer edition exists)
- Second source
- none opened · not found: The co-published Eur J Heart Fail 2021;23:352-380 abstract (PMID:33605000) states the same cut-offs but is the same document, not an independent source. The 2022 AHA/ACC/HFSA guideline abstract does not state them; its full text was not opened.
- Contested
- no: The same cut-offs appear in the co-published Eur J Heart Fail and J Card Fail versions; some guidelines describe HFmrEF differently in wording only (not opened).
Clinical implications of the universal definition for the prevention and treatment of heart failure
uhf2021_hf_ef_category@1.0In our words: Reduced ejection fraction: 40% or lower. Mildly reduced: 41% to 49%. Preserved: 50% or higher. Improved: an earlier ejection fraction of 40% or lower, a later one above 40%, and a rise of at least 10 points. Applies only once heart failure is diagnosed (2021 edition).
HFrEF, LVEF ≤ 40%; HF with mildly reduced ejection fraction (HFmrEF), LVEF of 41%–to 49%; ... HFpEF, LVEF ≥ 50%; and HF with improved ejection fraction (HFimpEF): baseline LVEF ≤ 40% with ≥10‐pt increase from baseline and second LVEF > 40%.
Chandramouli C, Stewart S, Almahmeed W, Lam CSP (Clin Cardiol 2022;45(Suppl 1):S2-S12, doi:10.1002/clc.23842) (2022) · Section 1.3 'New universal definition' (LVEF classification; Figure 2) · source
open licence: CC BY 4.0, attribution: Chandramouli C, Stewart S, Almahmeed W, Lam CSP. Clinical implications of the universal definition for the prevention and treatment of heart failure. Clin Cardiol 2022;45(Suppl 1):S2-S12, doi:10.1002/clc.23842. Licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). No endorsement by the cited bodies is implied.
- Universal Definition and Classification of Heart Failure, HFSA, HFA-ESC and JHFS (J Card Fail 2021;27:387-413; Eur J Heart Fail 2021;23:352-380) (2021), Abstract · link — earlier primary of this entry; numbers restated; text not reproduced
- Second Universal Definition of Heart Failure, AHA/ACC/ESC/WHF (Eur Heart J 2026;47:4357-74) (2026) — not opened; reported (secondary summary) to drop fixed cut-offs between reduced and preserved EF
- Accelerating heart failure research, National Heart, Lung, and Blood Institute (2022) · link — federal cross-check; uses below 40% (not 40% or lower) for reduced EF; not used for the bands
- ICD-10-CM FY2027 tabular list (I50.2-, I50.3-), CDC/NCHS (2026), I50.2-, I50.3- · link — coding terms: reduced EF under systolic HF, preserved EF under diastolic HF; no index entry for mildly reduced or improved EF
Review
Reviewed only when both a clinical review and a coding review are recorded as approved.
Clinical review: none recorded yet.
Coding review: none recorded yet.